Anastrozole

Introduction

Anastrozole is a prescription medication used to treat breast cancer in postmenopausal women. It’s part of a class of drugs called aromatase inhibitors, which lower estrogen levels in the body. Reducing estrogen helps slow or stop the growth of certain types of breast cancer that need estrogen to grow.

Uses

• Treats hormone receptor-positive breast cancer in postmenopausal women

• Often used as first-line therapy or after surgery, radiation, or chemotherapy

• It may be used to reduce the risk of cancer recurrence

How It Works

Anastrozole blocks the enzyme aromatase, which converts androgens into estrogen. Stopping this conversion significantly lowers estrogen levels in the body. Since some breast cancers grow in response to estrogen, reducing its presence helps to slow or shrink the tumor.

Side Effects and Precautions

Common Side Effects:

• Hot flashes

• Joint or muscle pain

• Weakness or fatigue

• Headache

• Nausea

Serious (but less common) Side Effects:

• Osteoporosis or bone fractures

• Increased cholesterol levels

• Liver function changes

• Allergic reactions (rash, swelling, trouble breathing)

Precautions:

• Not for use in premenopausal women

• Regular bone density checks may be needed

• Use caution if you have liver problems or osteoporosis

• Let your doctor know about any medications you’re taking, especially hormone therapies